Fructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism.

Zhou, Jing; Yao, Nan; Wang, Shuxia; An, Dongchen; Cao, Kangna; Wei, Jiali; Li, Ning; Zhao, Di; Wang, Lirui; Chen, Xijing; Lu, Yang

Zhou, Jing; Yao, Nan; Wang, Shuxia; An, Dongchen; Cao, Kangna; Wei, Jiali; Li, Ning; Zhao, Di; Wang, Lirui; Chen, Xijing; Lu, Yang.

Afiliação

Zhou J; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China; Nanjing University of Chinese Medicine, Department of Pharmaceutical Analysis and Metabolomics, Affiliated Hospital of Integrated Traditional Chinese and
Yao N; Nanjing University of Chinese Medicine, Department of Pharmaceutical Analysis and Metabolomics, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Hongshan Road Shizi Street No. 100, 210028 Nanjing, Jiangsu province, China.
Wang S; Nanjing University of Chinese Medicine, Department of Pharmaceutical Analysis and Metabolomics, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Hongshan Road Shizi Street No. 100, 210028 Nanjing, Jiangsu province, China.
An D; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China.
Cao K; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China.
Wei J; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China.
Li N; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China.
Zhao D; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China.
Wang L; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China. Electronic address: wanglirui@cpu.edu.cn.
Chen X; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China. Electronic address: chenxj_lab@hotmail.com.
Lu Y; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China. Electronic address: luyangcpu@hotmail.com.

J Ethnopharmacol ; 235: 47-55, 2019 May 10.

Article em En | MEDLINE | ID: mdl-30735766

Assuntos

Gardenia/química; Gastroenteropatias/induzido quimicamente; Inflamação/induzido quimicamente; Extratos Vegetais/toxicidade; Animais; Ácido Araquidônico/metabolismo; Cromatografia Líquida de Alta Pressão; Gastroenteropatias/patologia; Inflamação/patologia; Masculino; Espectrometria de Massas; Medicina Tradicional Chinesa/efeitos adversos; Metabolômica; Camundongos; Fenilalanina/metabolismo; Taurina/análogos & derivados; Taurina/metabolismo; Vitamina B 6/metabolismo

Palavras-chave

Fructus Gardeniae; Gastrointestinal injury; HPLC-TOF-MS/MS; Metabolomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Gardenia / Gastroenteropatias / Inflamação Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2019 Tipo de documento: Article

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