Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN).

Tuladhar, Rubina; Yarravarapu, Nageswari; Ma, Yuyong; Zhang, Chengwei; Herbert, Jeremiah; Kim, James; Chen, Chuo; Lum, Lawrence

Tuladhar, Rubina; Yarravarapu, Nageswari; Ma, Yuyong; Zhang, Chengwei; Herbert, Jeremiah; Kim, James; Chen, Chuo; Lum, Lawrence.

Afiliação

Tuladhar R; From the Departments of Cell Biology.
Yarravarapu N; From the Departments of Cell Biology.
Ma Y; Biochemistry, and.
Zhang C; Biochemistry, and.
Herbert J; From the Departments of Cell Biology.
Kim J; Internal Medicine and james.kim@utsouthwestern.edu.
Chen C; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Lum L; Biochemistry, and chuo.chen@utsouthwestern.edu.

J Biol Chem ; 294(16): 6273-6282, 2019 04 19.

Article em En | MEDLINE | ID: mdl-30737280

Assuntos

Aciltransferases/metabolismo; Ácidos Graxos/metabolismo; Proteínas de Membrana/metabolismo; Processamento de Proteína Pós-Traducional; Via de Sinalização Wnt; Acilação; Aciltransferases/genética; Animais; Células COS; Caenorhabditis elegans; Galinhas; Chlorocebus aethiops; Ácidos Graxos/genética; Células HEK293; Células HeLa; Humanos; Proteínas de Membrana/genética; Camundongos; Camundongos Knockout; Schistosoma mansoni; Xenopus

Palavras-chave

Porcupine (PORCN); Wnt pathway; Wnt signaling; Wntless (WLS); acyltransferase; fatty acid; fatty acylation; membrane-bound O-acyltransferase (MBOAT); palmitoleation; posttranslational modification (PTM); signal transduction

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aciltransferases / Processamento de Proteína Pós-Traducional / Ácidos Graxos / Via de Sinalização Wnt / Proteínas de Membrana Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google