The Effect of Different Exercise Modes on Domain-Specific Cognitive Function in Patients Suffering from Parkinson's Disease: A Systematic Review of Randomized Controlled Trials.
J Parkinsons Dis
; 9(1): 73-95, 2019.
Article
em En
| MEDLINE
| ID: mdl-30741688
ABSTRACT
BACKGROUND:
Supervised exercise training alleviates motor symptoms in people with Parkinson's disease (PD). However, the efficacy of exercise to improve nonmotor symptoms such as cognitive function is less well known.OBJECTIVE:
To systematically review evidence on the efficacy of different exercise modes (coordination exercise, resistance exercise, aerobic exercise) on domain-specific cognitive function in patients with PD.METHODS:
Parallel-group randomized controlled trials published before March 2018 were included. Primary outcome measures included global cognitive function and its subdomains, and the Unified Parkinson's Disease Rating Scale was included as a secondary outcome. Methodological quality was assessed using the Physiotherapy Evidence Database scale.RESULTS:
The literature search yielded 2,000 articles, of which 11 met inclusion criteria. 508 patients (mean age 68±4 years) were included with a disease severity from 1 to 4 on the Hoehn & Yahr stage scale. Overall study quality was modest (mean 6±2, range 3-8/10). In 5 trials a significant between-group effect size (ES) was identified for tests of specific cognitive domains, including a positive effect of aerobic exercise on memory (ESâ=â2.42) and executive function (ESâ=â1.54), and of combined resistance and coordination exercise on global cognitive function (ESâ=â1.54). Two trials found a significant ES for coordination exercise (ESâ=â0.84-1.88), which led to improved executive function compared with that of non-exercising control subjects.CONCLUSION:
All modes of exercise are associated with improved cognitive function in individuals with PD. Aerobic exercise tended to best improve memory; however, a clear effect of exercise mode was not identified.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Avaliação de Resultados em Cuidados de Saúde
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Terapia por Exercício
/
Disfunção Cognitiva
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
J Parkinsons Dis
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha