Defining Macrophages in the Heart One Cell at a Time.

Koelwyn, Graeme J; Moore, Kathryn J

Koelwyn, Graeme J; Moore, Kathryn J.

Afiliação

Koelwyn GJ; Department of Medicine, Marc and Ruti Bell Program for Vascular Biology and Disease, The Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY, USA.
Moore KJ; Department of Medicine, Marc and Ruti Bell Program for Vascular Biology and Disease, The Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY, USA. Electronic address: Kathryn.moore@nyulangone.org.

Trends Immunol ; 40(3): 179-181, 2019 03.

Article em En | MEDLINE | ID: mdl-30745266

ABSTRACT

ABSTRACT

Macrophages in the heart have dual roles in injury and repair after myocardial infarction, and understanding the two sides of this coin using traditional 'bulk cell' technologies has been challenging. By combining genetic fate-mapping and single-cell transcriptomics, a new study (Nat. Immunol. 2019;2029-39) reveals how distinct macrophage populations expand and diverge across the healthy heart and after infarction.

Assuntos

Macrófagos/imunologia; Infarto do Miocárdio/imunologia; Miocárdio/patologia; Animais; Técnicas de Reprogramação Celular; Humanos; Camundongos; Análise de Célula Única; Transcriptoma; Cicatrização

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Macrófagos / Infarto do Miocárdio / Miocárdio Limite: Animals / Humans Idioma: En Revista: Trends Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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