Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro.
Trans R Soc Trop Med Hyg
; 82(5): 709-14, 1988.
Article
em En
| MEDLINE
| ID: mdl-3075357
ABSTRACT
A comparative study showed that 5 laboratory strains of Trypanosoma cruzi could be divided into a non-responsive group (Sonya clone and Colombiana) and a responsive group (Tulahuén, Y and Peru), based on long-term treatment of mouse infections with nifurtimox and benznidazole. In vitro sensitivity of epimastigotes and blood-stream trypomastigotes in macrophage cultures did not distinguish the strains, nor did the rate of development of nifurtimox resistance by epimastigote cultures. 7 novel anti-T. cruzi compounds also behaved similarly with respect to the 2 groups. A small decrease in sensitivity was observed in vitro by non-responsive strains of T. cruzi after re-isolation from treated mice. It is postulated that there could be an immunological component involved in successful treatment of T. cruzi infection.
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Base de dados:
MEDLINE
Assunto principal:
Trypanosoma cruzi
Limite:
Animals
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Reino Unido