A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1<sup>G93A</sup> Rats.

Rehorová, Monika; Vargová, Ingrid; Forostyak, Serhiy; Vacková, Irena; Turnovcová, Karolína; Kupcová Skalníková, Helena; Vodicka, Petr; Kubinová, Sárka; Syková, Eva; Jendelová, Pavla

A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1^G93A Rats.

Rehorová, Monika; Vargová, Ingrid; Forostyak, Serhiy; Vacková, Irena; Turnovcová, Karolína; Kupcová Skalníková, Helena; Vodicka, Petr; Kubinová, Sárka; Syková, Eva; Jendelová, Pavla.

Afiliação

Rehorová M; Institute of Experimental Medicine, Czech Academy of Science, Prague, Czech Republic.
Vargová I; Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Forostyak S; Institute of Experimental Medicine, Czech Academy of Science, Prague, Czech Republic.
Vacková I; Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Turnovcová K; Institute of Experimental Medicine, Czech Academy of Science, Prague, Czech Republic.
Kupcová Skalníková H; Prime Cell Advanced Therapy A.S., Brno, Czech Republic.
Vodicka P; Institute of Experimental Medicine, Czech Academy of Science, Prague, Czech Republic.
Kubinová S; Institute of Experimental Medicine, Czech Academy of Science, Prague, Czech Republic.
Syková E; Institute of Animal Physiology and Genetics, Czech Academy of Science, Libechov, Czech Republic.
Jendelová P; Institute of Animal Physiology and Genetics, Czech Academy of Science, Libechov, Czech Republic.

Stem Cells Transl Med ; 8(6): 535-547, 2019 06.

Article em En | MEDLINE | ID: mdl-30802001

Assuntos

Esclerose Lateral Amiotrófica/terapia; Transplante de Células-Tronco Mesenquimais; Necroptose; Medula Espinal/metabolismo; Superóxido Dismutase-1/genética; Animais; Proteína Beclina-1/metabolismo; Caspase 9/metabolismo; Modelos Animais de Doenças; Humanos; Injeções Intramusculares; Injeções Espinhais; Longevidade; Células-Tronco Mesenquimais/citologia; Células-Tronco Mesenquimais/metabolismo; Neurônios Motores/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Músculo Quadríceps/citologia; Músculo Quadríceps/metabolismo; Ratos; Ratos Sprague-Dawley; Ratos Transgênicos; Proteína Serina-Treonina Quinases de Interação com Receptores; Medula Espinal/citologia; Superóxido Dismutase-1/metabolismo

Palavras-chave

Amyotrophic lateral sclerosis; Apoptosis; Autophagy; Mesenchymal stem cells; Necroptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medula Espinal / Transplante de Células-Tronco Mesenquimais / Superóxido Dismutase-1 / Necroptose / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Stem Cells Transl Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: República Tcheca

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