Help from my friends-cooperation of BMAL1 with noncircadian transcription factors.
Genes Dev
; 33(5-6): 255-257, 2019 03 01.
Article
em En
| MEDLINE
| ID: mdl-30824531
ABSTRACT
The circadian clock in the suprachiasmatic nucleus (SCN) of mammals drives 24-h rhythms of sleep/wake cycles. Peripheral clocks present in other organs coordinate local and global physiology according to rhythmic signals from the SCN and via metabolic cues. The core circadian clockwork is identical in all cells. However, there is only a small amount of overlap of the circadian transcriptomes in different organs and tissues. A novel study by Beytebiere and colleagues (pp. 294-309) indicates that the regulation of tissue-specific rhythmic gene expression involves the cooperation of the circadian transcription factor (TF) BMAL1CLOCK with tissue-specific TFs (ts-TFs) and correlates with the potential of BMAL1CLOCK to facilitate rhythmic enhancer-enhancer interactions.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas CLOCK
/
Relógios Circadianos
Limite:
Animals
Idioma:
En
Revista:
Genes Dev
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha