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Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity.
Hayashi, Yumi; Fukasawa, Wataru; Hirose, Tomoyasu; Iwatsuki, Masato; Hokari, Rei; Ishiyama, Aki; Kanaida, Masahiro; Nonaka, Kenichi; Také, Akira; Otoguro, Kazuhiko; O Mura, Satoshi; Shiomi, Kazuro; Sunazuka, Toshiaki.
Afiliação
  • Hayashi Y; Graduate School of Infection Control Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Fukasawa W; Graduate School of Infection Control Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Hirose T; Graduate School of Infection Control Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Iwatsuki M; Kitasato Institute for Life Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Hokari R; Graduate School of Infection Control Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Ishiyama A; Kitasato Institute for Life Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Kanaida M; Kitasato Institute for Life Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Nonaka K; Graduate School of Infection Control Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Také A; Kitasato Institute for Life Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Otoguro K; Graduate School of Infection Control Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • O Mura S; Graduate School of Infection Control Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Shiomi K; Kitasato Institute for Life Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
  • Sunazuka T; Kitasato Institute for Life Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku , Tokyo 108-8641 , Japan.
Org Lett ; 21(7): 2180-2184, 2019 04 05.
Article em En | MEDLINE | ID: mdl-30859827
ABSTRACT
Kozupeptins A and B, novel antimalarial lipopeptides, were isolated from the culture broths of Paracamarosporium sp. FKI-7019. They exhibited potent antimalarial activity against chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro. The structural elucidation was accomplished by a combination of spectroscopic analyses and chemical approaches including a total synthesis of kozupeptin A. Synthetic kozupeptin A demonstrated a therapeutic effect in vivo, and an intermediate exhibited much higher antimalarial activity than kozupeptin A.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Cloroquina / Antimaláricos Limite: Animals Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Cloroquina / Antimaláricos Limite: Animals Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão