Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sjögren's syndrome.
Amino Acids
; 52(2): 119-127, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-30863888
ABSTRACT
It was found recently that acrolein (CH2=CH-CHO), mainly produced from spermine, is more toxic than ROS (reactive oxygen species, O2-·, H2O2, and ·OH). In this review, we describe how the seriousness of brain infarction, dementia, renal failure, and SjÓ§gren's syndrome is correlated with acrolein. In brain infarction and dementia, it was possible to identify incipient patients with high sensitivity and specificity by measuring protein-conjugated acrolein (PC-Acro) in plasma together with IL-6 and CRP in brain infarction and Aß40/42 in dementia. The level of PC-Acro in plasma and saliva correlated with the seriousness of renal failure and SjÓ§gren's syndrome, respectively. Thus, development of acrolein scavenger medicines containing SH-group such as N-acetylcysteine derivatives is important to maintain QOL (quality of life) of the elderly.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acroleína
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Síndrome de Sjogren
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Acidente Vascular Cerebral
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Demência
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Insuficiência Renal
Limite:
Animals
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Humans
Idioma:
En
Revista:
Amino Acids
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão