CD81 Expression in the Differential Diagnosis of Chronic Lymphocytic Leukemia.
Clin Lab
; 65(3)2019 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-30868852
ABSTRACT
BACKGROUND:
Immunophenotyping has a central role in CLL. However, CLL is a very heterogenous disease, both morphologically and immunophenotypically; thus, its diagnosis may prove a challenge. We investigated CD81 ex-pression in the differential diagnosis of CLL and MCL.METHODS:
We retrospectively examined CD81 expression with 8 color Multiparameter Flow cytometry devices in 101 CLL and 19 MCL cases.RESULTS:
We found negative CD81 expression in CLL cases whereas it was positive in MCL cases.CONCLUSIONS:
Our results suggest that CD81 may be a valuable marker for the differential diagnosis of CLL. We are of the opinion that it should be definitely included in the diagnostic algorithm for CLL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Linfocítica Crônica de Células B
/
Tetraspanina 28
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Clin Lab
Assunto da revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2019
Tipo de documento:
Article