A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes.
FEBS Lett
; 593(8): 831-841, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30883722
ABSTRACT
Recent studies have revealed a possible link between the activities of polymorphic arylamine N-acetyltransferases (NATs) and energy metabolism. We used a Nat1/Nat2 double knockout (KO) mouse model to demonstrate that ablation of the two Nat genes is associated with modest, intermittent alterations in respiratory exchange rate. Pyruvate tolerance tests show that double KO mice have attenuated hepatic gluconeogenesis when maintained on a high-fat/high-sucrose diet. Absence of the two Nat genes also leads to an increase in the hepatic concentration of coenzyme A in mice fed a high-fat/high-sucrose diet. Our results suggest a modest involvement of NAT in energy metabolism in mice, which is consistent with the absence of major phenotypic deregulation of energy metabolism in slow human acetylators.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arilamina N-Acetiltransferase
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Metabolismo Energético
Limite:
Animals
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Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
França