Novel two-chain fatty acid-based lipids for development of vancomycin pH-responsive liposomes against <i>Staphylococcus aureus</i> and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA).

Makhathini, Sifiso S; Kalhapure, Rahul S; Jadhav, Mahantesh; Waddad, Ayman Y; Gannimani, Ramesh; Omolo, Calvin A; Rambharose, Sanjeev; Mocktar, Chunderika; Govender, Thirumala

Novel two-chain fatty acid-based lipids for development of vancomycin pH-responsive liposomes against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA).

Makhathini, Sifiso S; Kalhapure, Rahul S; Jadhav, Mahantesh; Waddad, Ayman Y; Gannimani, Ramesh; Omolo, Calvin A; Rambharose, Sanjeev; Mocktar, Chunderika; Govender, Thirumala.

Afiliação

Makhathini SS; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal , Durban , South Africa.
Kalhapure RS; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal , Durban , South Africa.
Jadhav M; School of Pharmacy, The University of Texas , El Paso , TX , USA.
Waddad AY; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal , Durban , South Africa.
Gannimani R; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal , Durban , South Africa.
Omolo CA; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal , Durban , South Africa.
Rambharose S; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal , Durban , South Africa.
Mocktar C; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal , Durban , South Africa.
Govender T; Division of Emergency Medicine, Department of Surgery, University of Cape Town , Cape Town , South Africa.

J Drug Target ; 27(10): 1094-1107, 2019 12.

Article em En | MEDLINE | ID: mdl-30901236

Assuntos

Ácidos Graxos/química; Lipídeos/química; Lipossomos/química; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Infecções Estafilocócicas/tratamento farmacológico; Vancomicina/química; Vancomicina/farmacologia; Células A549; Animais; Antibacterianos/química; Antibacterianos/farmacologia; Linhagem Celular Tumoral; Liberação Controlada de Fármacos/efeitos dos fármacos; Células Hep G2; Humanos; Concentração de Íons de Hidrogênio; Células MCF-7; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Testes de Sensibilidade Microbiana

Palavras-chave

MRSA; Vancomycin; fatty acid-based lipids; pH-responsive liposome; targeted drug delivery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Vancomicina / Staphylococcus aureus Resistente à Meticilina / Ácidos Graxos / Lipídeos / Lipossomos Limite: Animals / Humans / Male Idioma: En Revista: J Drug Target Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: África do Sul

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