TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics.

Chaligne, Ronan; Nam, Anna S; Landau, Dan A

Chaligne, Ronan; Nam, Anna S; Landau, Dan A.

Afiliação

Chaligne R; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; New York Genome Center, New York, NY, USA.
Nam AS; New York Genome Center, New York, NY, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Landau DA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; New York Genome Center, New York, NY, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. Electronic address: dlandau@nygenome.org.

Mol Cell ; 73(6): 1092-1094, 2019 03 21.

Article em En | MEDLINE | ID: mdl-30901562

ABSTRACT

ABSTRACT

In this issue of Molecular Cell, Rodriguez-Meira et al. (2019) present TARGET-seq, an elegant single-cell method that genotypes somatic mutations and captures whole transcriptomes in the same tumor cells, thus paving the way to directly link somatic mutations with resulting transcriptional phenotypes in clonally diverse cancer populations.

Assuntos

Neoplasias; Análise de Célula Única; Genótipo; Humanos; Mutação; Análise de Sequência de RNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise de Célula Única / Neoplasias Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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