[Serum metabolomics of preterm and full-term infants based on gas chromatography-mass spectrometry].
Zhongguo Dang Dai Er Ke Za Zhi
; 21(3): 259-264, 2019 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-30907351
ABSTRACT
OBJECTIVE:
To study the features of serum metabolites in preterm infants based on gas chromatography-mass spectrometry (GC-MS), and to find differentially expressed metabolites in the serum of preterm infants.METHODS:
Serum samples were collected from 19 preterm infants and 20 full-term infants before feeding. GC-MS was used to measure metabolic profiles, and the metabolic features of 397 serum metabolites in preterm infants were analyzed.RESULTS:
There was a significant difference in serum metabolic features between the preterm and full-term infants before feeding. There were significant differences between the full-term and preterm infants in the levels of metabolites such as O-phosphonothreonine, digicitrin, tannic acid, and fructose-1,6-diphosphate (P<0.01), suggesting that the above differentially expressed metabolites were highly differentiated between the preterm and full-term infants. Most differentially expressed metabolites were involved in the metabolic pathways such as ABC transporters, ß-alanine and pyrimidines and were correlated with some clinical parameters (albumin and total bilirubin) (P<0.05).CONCLUSIONS:
There is a significant difference in serum metabolites between preterm and full-term infants before feeding. Metabolomics plays an important role in improving metabolic disorders and exploring metabolism-related diseases in preterm infants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Metaboloma
/
Metabolômica
Limite:
Humans
/
Newborn
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China