Heroin addiction engages negative emotional learning brain circuits in rats.
J Clin Invest
; 129(6): 2480-2484, 2019 03 26.
Article
em En
| MEDLINE
| ID: mdl-30913040
ABSTRACT
Opioid use disorder (OUD) is associated with the emergence of persistent negative emotional states during drug abstinence that drive compulsive drug taking and seeking. Functional magnetic resonance imaging (fMRI) in rats identified neurocircuits that were activated by stimuli that were previously paired with heroin withdrawal. The activation of amygdala and hypothalamic circuits was related to the degree of heroin dependence, supporting the significance of conditioned negative affect in sustaining compulsive-like heroin seeking and taking and providing neurobiological insights into the drivers of the current opioid crisis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Emoções
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Dependência de Heroína
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Tonsila do Cerebelo
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Hipotálamo
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Aprendizagem
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Rede Nervosa
Limite:
Animals
Idioma:
En
Revista:
J Clin Invest
Ano de publicação:
2019
Tipo de documento:
Article