Enantioselective anti-Mannich reaction catalyzed by modularly designed organocatalysts.
Tetrahedron
; 74(42): 6166-6172, 2018 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-30923409
ABSTRACT
A highly stereoselective method for achieving the anti-Mannich reaction of aldehydes and ketones with ethyl (4-methoxyphenylimino)acetate was realized using the modularly designed organocatalysts (MDOs) self-assembled from cinchona alkaloid derivatives and (A)-pyrrolidien-3-carboxylic acid in the reaction media. The desired anti-Mannich products were obtained in good to excellent yields (up to 93%), excellent diastereoselectivities (up to 991 dr), and good to high enantioselectivities (up to 99% ee).
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Tetrahedron
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos