Understanding the link between insulin resistance and Alzheimer's disease: Insights from animal models.
Exp Neurol
; 316: 1-11, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30930096
ABSTRACT
Alzheimer's disease (AD) is a devastating neurodegenerative disease affecting millions of people worldwide. AD is characterized by a profound impairment of higher cognitive functions and still lacks any effective disease-modifying treatment. Defective insulin signaling has been implicated in AD pathophysiology, but the mechanisms underlying this process are not fully understood. Here, we review the molecular mechanisms underlying defective brain insulin signaling in rodent models of AD, and in a non-human primate (NHP) model of the disease that recapitulates features observed in AD brains. We further highlight similarities between the NHP and human brains and discuss why NHP models of AD are important to understand disease mechanisms and to improve the translation of effective therapies to humans. We discuss how studies using different animal models have contributed to elucidate the link between insulin resistance and AD.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Doença de Alzheimer
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Neurol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá