The effect of minimally invasive surgical aortic valve replacement on postoperative pulmonary and skeletal muscle function.
Exp Physiol
; 104(6): 855-865, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30938881
ABSTRACT
NEW FINDINGS:
What is the central question of this study? How does surgical aortic valve replacement affect cardiopulmonary and muscle function during exercise? What is the main finding and its importance? Early after the surgical replacement of the aortic valve a significant decline in pulmonary function was observed, which was followed by a decline in skeletal muscle function in the subsequent weeks of recovery. These date reiterate, despite restoration of aortic valve function, the need for a tailored rehabilitation programme for the respiratory and peripheral muscular system. ABSTRACT Suboptimal post-operative improvements in functional capacity are often observed after minimally invasive aortic valve replacement (mini-AVR). It remains to be studied how AVR affects the cardiopulmonary and skeletal muscle function during exercise to explain these clinical observations and to provide a basis for improved/tailored post-operative rehabilitation. Twenty-two patients with severe aortic stenosis (AS) (aortic valve area (AVA) <1.0 cm²) were pre-operatively compared to 22 healthy controls during submaximal constant-workload endurance-type exercise for oxygen uptake ( VÌO2 ), carbon dioxide output ( VÌCO2 ), respiratory gas exchange ratio, expiratory volume ( VÌE ), ventilatory equivalents for O2 ( VÌE / VÌO2 ) and CO2 ( VÌE / VÌCO2 ), respiratory rate (RR), tidal volume (Vt ), heart rate (HR), oxygen pulse ( VÌO2 /HR), blood lactate, Borg ratings of perceived exertion (RPE) and exercise-onset VÌO2 kinetics. These exercise tests were repeated at 5 and 21 days after AVR surgery (n = 14), along with echocardiographic examinations. Respiratory exchange ratio and ventilatory equivalents ( VÌE / VÌO2 and VÌE / VÌCO2 ) were significantly elevated, VÌO2 and VÌO2 /HR were significantly lowered, and exercise-onset VÌO2 kinetics were significantly slower in AS patients vs. healthy controls (P < 0.05). Although the AVA was restored by mini-AVR in AS patients, VÌE / VÌO2 and VÌE / VÌCO2 further worsened significantly within 5 days after surgery, accompanied by elevations in Borg RPE, VÌE and RR, and lowered Vt . At 21 days after mini-AVR, exercise-onset VÌO2 kinetics further slowed significantly (P < 0.05). A decline in pulmonary function was observed early after mini-AVR surgery, which was followed by a decline in skeletal muscle function in the subsequent weeks of recovery. Therefore, a tailored rehabilitation programme should include training modalities for the respiratory and peripheral muscular system.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Valva Aórtica
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Estenose da Valva Aórtica
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Músculo Esquelético
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Pulmão
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Exp Physiol
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Bélgica