Cytology material is equivalent to tumor tissue in determining mutations of BRCA 1/2 genes in patients with tubo-ovarian high grade serous carcinoma.

Gornjec, Andreja; Novakovic, Srdjan; Stegel, Vida; Hocevar, Marko; Pohar Marinsek, Ziva; Gazic, Barbara; Krajc, Mateja; Skof, Erik

Gornjec, Andreja; Novakovic, Srdjan; Stegel, Vida; Hocevar, Marko; Pohar Marinsek, Ziva; Gazic, Barbara; Krajc, Mateja; Skof, Erik.

Afiliação

Gornjec A; Department of Gynecologic Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Novakovic S; Department of Molecular diagnostics, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Stegel V; Department of Molecular diagnostics, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Hocevar M; Department of Surgical Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Pohar Marinsek Z; Department of Cythopathology, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Gazic B; Department of Pathology, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Krajc M; Department of Genetic counselling, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Skof E; Department of Medical oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia. eskof@onko-i.si.

BMC Cancer ; 19(1): 296, 2019 Apr 02.

Article em En | MEDLINE | ID: mdl-30940100

Assuntos

Proteína BRCA1/genética; Proteína BRCA2/genética; Análise Mutacional de DNA/métodos; Mutação; Neoplasias Ovarianas/patologia; Adulto; Idoso; Técnicas Citológicas/métodos; Feminino; Mutação em Linhagem Germinativa; Humanos; Pessoa de Meia-Idade; Neoplasias Ovarianas/diagnóstico; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/metabolismo

Palavras-chave

BRCA1/2 mutation; BRCA1/2 mutation testing; Cytological samples; Formalin fixed paraffin embedded samples; High-grade serous cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Análise Mutacional de DNA / Proteína BRCA1 / Proteína BRCA2 / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Eslovênia

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