HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression.

Hu, Tianjing; Schreiter, Friederike C; Bagchi, Rushita A; Tatman, Philip D; Hannink, Mark; McKinsey, Timothy A

Hu, Tianjing; Schreiter, Friederike C; Bagchi, Rushita A; Tatman, Philip D; Hannink, Mark; McKinsey, Timothy A.

Afiliação

Hu T; Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Schreiter FC; Department of Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany; German Centre for Cardiovascular Research, Heidelberg/Mannheim, Germany.
Bagchi RA; Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Tatman PD; Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Hannink M; Bond Life Sciences Center and Department of Biochemistry, University of Missouri, Columbia, Missouri 65211.
McKinsey TA; Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045. Electronic address: timothy.mckinsey@ucdenver.edu.

J Biol Chem ; 294(21): 8640-8652, 2019 05 24.

Article em En | MEDLINE | ID: mdl-30962285

Assuntos

Regulação Enzimológica da Expressão Gênica; Histona Desacetilases/biossíntese; Miócitos Cardíacos/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo; Animais; Benzamidas/farmacologia; Células HEK293; Histona Desacetilases/genética; Humanos; Mitocôndrias Cardíacas/genética; Mitocôndrias Cardíacas/metabolismo; Miócitos Cardíacos/citologia; Fator 2 Relacionado a NF-E2/genética; Oxidiazóis/farmacologia; Domínios Proteicos; Ratos; Espécies Reativas de Oxigênio/metabolismo; Proteínas Repressoras/biossíntese; Proteínas Repressoras/genética

Palavras-chave

NRF2; cardiac hypertrophy; cardiomyocyte; histone deacetylase; histone deacetylase (HDAC); mitochondria; nuclear factor 2 (erythroid-derived 2like factor, NFE2L2, Nrf2); oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Estresse Oxidativo / Miócitos Cardíacos / Fator 2 Relacionado a NF-E2 / Histona Desacetilases Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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