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Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.
Deguchi, Sayaka; Yamashita, Tomoki; Igai, Keisuke; Harada, Kazuo; Toba, Yukiko; Hirata, Kazumasa; Takayama, Kazuo; Mizuguchi, Hiroyuki.
Afiliação
  • Deguchi S; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.),
  • Yamashita T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.),
  • Igai K; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.),
  • Harada K; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.),
  • Toba Y; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.),
  • Hirata K; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.),
  • Takayama K; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.),
  • Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.),
Drug Metab Dispos ; 47(6): 632-638, 2019 06.
Article em En | MEDLINE | ID: mdl-30962288
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Taxa de Depuração Metabólica / Células-Tronco Pluripotentes Induzidas / Citocromo P-450 CYP2C19 / Clopidogrel / Cetoconazol / Fígado Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Taxa de Depuração Metabólica / Células-Tronco Pluripotentes Induzidas / Citocromo P-450 CYP2C19 / Clopidogrel / Cetoconazol / Fígado Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article