Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.

Irani, Seema; Sipe, Sarah N; Yang, Wanjie; Burkholder, Nathaniel T; Lin, Brian; Sim, Kelly; Matthews, Wendy L; Brodbelt, Jennifer S; Zhang, Yan

Irani, Seema; Sipe, Sarah N; Yang, Wanjie; Burkholder, Nathaniel T; Lin, Brian; Sim, Kelly; Matthews, Wendy L; Brodbelt, Jennifer S; Zhang, Yan.

Afiliação

Irani S; Department of Chemical Engineering, The University of Texas, Austin, Texas 78712; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Sipe SN; Department of Chemistry, The University of Texas, Austin, Texas 78712.
Yang W; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Burkholder NT; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Lin B; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Sim K; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Matthews WL; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.
Brodbelt JS; Department of Chemistry, The University of Texas, Austin, Texas 78712.
Zhang Y; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712; Institute for Cellular and Molecular Biology, The University of Texas, Austin, Texas 78712. Electronic address: jzhang@cm.utexas.edu.

J Biol Chem ; 294(21): 8592-8605, 2019 05 24.

Article em En | MEDLINE | ID: mdl-30971428

Assuntos

Proteínas de Drosophila/química; Proteínas Tirosina Fosfatases/química; RNA Polimerase II/química; Motivos de Aminoácidos; Animais; Proteínas de Drosophila/genética; Proteínas de Drosophila/metabolismo; Drosophila melanogaster; Fosforilação; Proteínas Tirosina Fosfatases/genética; Proteínas Tirosina Fosfatases/metabolismo; RNA Polimerase II/genética; RNA Polimerase II/metabolismo

Palavras-chave

CTD code; DNA transcription; RNA polymerase II; X-ray crystallography; intrinsically disordered protein; mass spectrometry (MS); phosphatase; phosphoryl motif; proline isomerization; tyrosine phosphorylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Polimerase II / Proteínas Tirosina Fosfatases / Proteínas de Drosophila Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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