Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.

Asquith, Christopher R M; Naegeli, Kaleb M; East, Michael P; Laitinen, Tuomo; Havener, Tammy M; Wells, Carrow I; Johnson, Gary L; Drewry, David H; Zuercher, William J; Morris, David C

Asquith, Christopher R M; Naegeli, Kaleb M; East, Michael P; Laitinen, Tuomo; Havener, Tammy M; Wells, Carrow I; Johnson, Gary L; Drewry, David H; Zuercher, William J; Morris, David C.

Afiliação

Asquith CRM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
Naegeli KM; Department of Pharmacology, School of Medicine , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
East MP; UNC Catalyst for Rare Diseases , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
Laitinen T; Department of Pharmacology, School of Medicine , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
Havener TM; School of Pharmacy, Faculty of Health Sciences , University of Eastern Finland , 70211 Kuopio , Finland.
Wells CI; UNC Catalyst for Rare Diseases , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
Johnson GL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
Drewry DH; Department of Pharmacology, School of Medicine , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
Zuercher WJ; Structural Genomics Consortium, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
Morris DC; Structural Genomics Consortium, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

J Med Chem ; 62(9): 4772-4778, 2019 05 09.

Article em En | MEDLINE | ID: mdl-30973735

Assuntos

Antineoplásicos/farmacologia; Peptídeos e Proteínas de Sinalização Intracelular/antagonistas & inibidores; Inibidores de Proteínas Quinases/farmacologia; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Aminoquinolinas/síntese química; Aminoquinolinas/metabolismo; Aminoquinolinas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Cordoma/tratamento farmacológico; Desenho de Fármacos; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/metabolismo; Células HEK293; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Simulação de Acoplamento Molecular; Ligação Proteica; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Quinazolinas/síntese química; Quinazolinas/metabolismo; Quinazolinas/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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