Design, Synthesis, and Evaluation of Monoamine Oxidase A Inhibitorsâ»Indocyanine Dyes Conjugates as Targeted Antitumor Agents.

Yang, Xiao-Guang; Mou, Yan-Hua; Wang, Yong-Jun; Wang, Jian; Li, Yan-Yu; Kong, Rui-Heng; Ding, Meng; Wang, Dun; Guo, Chun

Design, Synthesis, and Evaluation of Monoamine Oxidase A Inhibitorsâ»Indocyanine Dyes Conjugates as Targeted Antitumor Agents.

Yang, Xiao-Guang; Mou, Yan-Hua; Wang, Yong-Jun; Wang, Jian; Li, Yan-Yu; Kong, Rui-Heng; Ding, Meng; Wang, Dun; Guo, Chun.

Afiliação

Yang XG; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. xiaog_yang@163.com.
Mou YH; School of life sciences and biological pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. mouyanhua2018@163.com.
Wang YJ; Wuya College of innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. i_maple@163.com.
Wang J; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. jianwang@syphu.edu.cn.
Li YY; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. 18345384016@163.com.
Kong RH; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. krh2735@163.com.
Ding M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. dingmeng74376@126.com.
Wang D; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. wangduncn@163.com.
Guo C; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. chunguo@syphu.edu.cn.

Molecules ; 24(7)2019 Apr 10.

Article em En | MEDLINE | ID: mdl-30974737

Assuntos

Carbocianinas; Corantes Fluorescentes; Isoniazida; Simulação de Acoplamento Molecular; Inibidores da Monoaminoxidase; Monoaminoxidase; Proteínas de Neoplasias; Neoplasias da Próstata; Carbocianinas/síntese química; Carbocianinas/química; Carbocianinas/farmacologia; Corantes Fluorescentes/síntese química; Corantes Fluorescentes/química; Corantes Fluorescentes/farmacologia; Humanos; Isoniazida/química; Isoniazida/farmacologia; Masculino; Monoaminoxidase/química; Monoaminoxidase/metabolismo; Inibidores da Monoaminoxidase/síntese química; Inibidores da Monoaminoxidase/química; Inibidores da Monoaminoxidase/farmacologia; Proteínas de Neoplasias/antagonistas & inibidores; Proteínas de Neoplasias/metabolismo; Células PC-3; Neoplasias da Próstata/tratamento farmacológico; Neoplasias da Próstata/enzimologia; Neoplasias da Próstata/patologia

Palavras-chave

heptamethine cyanine dyes; isoniazid; molecular docking; monoamine oxidase A; prostate cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Carbocianinas / Simulação de Acoplamento Molecular / Corantes Fluorescentes / Isoniazida / Monoaminoxidase / Inibidores da Monoaminoxidase / Proteínas de Neoplasias Limite: Humans / Male Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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