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Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study.
Yang, Xin-Mei; Leroux, Stephanie; Storme, Thomas; Zhang, Dao-Lun; de Beaumais, Tiphaine Adam; Shi, Hai-Yan; Yang, Yi-Lei; Wang, Xiao-Ling; Zhao, Wei; Jacqz-Aigrain, Evelyne.
Afiliação
  • Yang XM; Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
  • Leroux S; Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, APHP, Paris, France.
  • Storme T; Neonatal Intensive Care Unit, CHU de Rennes, Rennes, France.
  • Zhang DL; Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, APHP, Paris, France.
  • de Beaumais TA; Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, APHP, Paris, France.
  • Shi HY; Precision Cancer Medicine Team, Institut Gustave Roussy, Villejuif, France.
  • Yang YL; Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
  • Wang XL; Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
  • Zhao W; Clinical Research Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
  • Jacqz-Aigrain E; Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China zhao4wei2@hotmail.com evelyne.jacqzaigrain@gmail.com.
Antimicrob Agents Chemother ; 63(7)2019 07.
Article em En | MEDLINE | ID: mdl-30988148
ABSTRACT
We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caspofungina Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caspofungina Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China