Fifty Shades of Microglia.
Trends Neurosci
; 42(7): 440-443, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31005331
ABSTRACT
In a recent study, Masuda and colleagues (Nature 2019;566388-392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microglia
/
Esclerose Múltipla
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Neurosci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos