Class I and Class II small leucine-rich proteoglycans in human cutaneous pacinian corpuscles.
Ann Anat
; 224: 62-72, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-31005573
ABSTRACT
Pacinian corpuscles are onion bulb-like multilayered mechanoreceptors that consist of a complicated structure of axon terminals, Schwann related cells (inner core), endoneural related cells (intermediate layer) and perineurial related cells (outer core-capsule). The cells forming those compartments are continuous and share the properties of that covering the nerve fibers. Small leucine-rich proteoglycans are major proteoglycans of the extracellular matrix and regulate collagen fibrillogenesis, cell signalling pathways and extracellular matrix assembly. Here we used immunohistochemistry to investigate the distribution of class I (biglycan, decorin, asporin, ECM2 and ECMX) and class II (fibromodulin, lumican, prolargin, keratocan and osteoadherin) small leucine-rich proteoglycans in human cutaneous Pacinian corpuscles. The distribution of these compounds was the inner core express decorin, biglycan, lumican, fibromodulin, osteoadherin; the intermediate layer display immunoreactivity for osteoadherin; the outer core biglycan, decorin, lumican, fibromodulin and osteoadherin; and the capsule contains biglycan, decorin, fibromodulin, and lumican. Asporin, prolargin and keratocan were undetectable. These results complement our knowledge about the distribution of small leucine-rich proteoglycans in human Pacinian corpuscles, and help to understand the composition of the extracellular matrix in these sensory formations.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Corpúsculos de Pacini
/
Proteoglicanas
Limite:
Adolescent
/
Adult
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Animals
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Child
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Humans
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Middle aged
Idioma:
En
Revista:
Ann Anat
Assunto da revista:
ANATOMIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Espanha