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The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.
Tirosh, Amir; Calay, Ediz S; Tuncman, Gurol; Claiborn, Kathryn C; Inouye, Karen E; Eguchi, Kosei; Alcala, Michael; Rathaus, Moran; Hollander, Kenneth S; Ron, Idit; Livne, Rinat; Heianza, Yoriko; Qi, Lu; Shai, Iris; Garg, Rajesh; Hotamisligil, Gökhan S.
Afiliação
  • Tirosh A; Dalia and David Arabov Endocrinology and Diabetes Research Center, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel. ghotamis@hsph.harvard.edu amir.tirosh@sheba.health.gov.il.
  • Calay ES; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Tuncman G; Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Claiborn KC; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Inouye KE; Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Eguchi K; Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Alcala M; Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Rathaus M; Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Hollander KS; Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Ron I; Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Livne R; Dalia and David Arabov Endocrinology and Diabetes Research Center, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
  • Heianza Y; Dalia and David Arabov Endocrinology and Diabetes Research Center, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
  • Qi L; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Shai I; Dalia and David Arabov Endocrinology and Diabetes Research Center, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
  • Garg R; Dalia and David Arabov Endocrinology and Diabetes Research Center, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
  • Hotamisligil GS; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Sci Transl Med ; 11(489)2019 04 24.
Article em En | MEDLINE | ID: mdl-31019023
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propionatos / Glucagon / Proteínas de Ligação a Ácido Graxo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propionatos / Glucagon / Proteínas de Ligação a Ácido Graxo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article