BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation.

Kerscher, Bernhard; Barlow, Jillian L; Rana, Batika M; Jolin, Helen E; Gogoi, Mayuri; Bartholomew, Michelle A; Jhamb, Deepali; Pandey, Ashutosh; Tough, David F; van Oosterhout, Antoon J M; McKenzie, Andrew N J

Kerscher, Bernhard; Barlow, Jillian L; Rana, Batika M; Jolin, Helen E; Gogoi, Mayuri; Bartholomew, Michelle A; Jhamb, Deepali; Pandey, Ashutosh; Tough, David F; van Oosterhout, Antoon J M; McKenzie, Andrew N J.

Afiliação

Kerscher B; Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.
Barlow JL; Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.
Rana BM; Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.
Jolin HE; Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.
Gogoi M; Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.
Bartholomew MA; Allergic Inflammation DPU, Respiratory Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage, United Kingdom.
Jhamb D; Computational Biology, GSK R&D, Collegeville, PA, United States.
Pandey A; Computational Biology, GSK R&D, Collegeville, PA, United States.
Tough DF; Epigenetics DPU, Immunoinflammation Therapy Area Unit, Glaxo Smith Kline, Medicines Research Centre, Stevenage, United Kingdom.
van Oosterhout AJM; Allergic Inflammation DPU, Respiratory Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage, United Kingdom.
McKenzie ANJ; Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.

Front Immunol ; 10: 678, 2019.

Article em En | MEDLINE | ID: mdl-31024538

Assuntos

Anti-Inflamatórios/farmacologia; Hipersensibilidade/tratamento farmacológico; Pneumonia/tratamento farmacológico; Proteínas/antagonistas & inibidores; Alérgenos/imunologia; Animais; Asma/tratamento farmacológico; Asma/imunologia; Asma/metabolismo; Citocinas/imunologia; Citocinas/metabolismo; Humanos; Hipersensibilidade/imunologia; Hipersensibilidade/metabolismo; Imunidade Inata/efeitos dos fármacos; Imunidade Inata/imunologia; Pulmão/efeitos dos fármacos; Pulmão/imunologia; Pulmão/metabolismo; Linfócitos/efeitos dos fármacos; Linfócitos/imunologia; Linfócitos/metabolismo; Camundongos; Pneumonia/imunologia; Pneumonia/metabolismo

Palavras-chave

ILC2; Th2; allergy; asthma; bromodomain; extra-terminal motif protein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / Proteínas / Hipersensibilidade / Anti-Inflamatórios Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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