A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms.

Yang, Na; Teng, Da; Mao, Ruoyu; Hao, Ya; Wang, Xiao; Wang, Zhenlong; Wang, Xiumin; Wang, Jianhua

Yang, Na; Teng, Da; Mao, Ruoyu; Hao, Ya; Wang, Xiao; Wang, Zhenlong; Wang, Xiumin; Wang, Jianhua.

Afiliação

Yang N; Team of Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, People's Republic of China.
Teng D; Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing, 100081, People's Republic of China.
Mao R; Team of Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, People's Republic of China.
Hao Y; Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing, 100081, People's Republic of China.
Wang X; Team of Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, People's Republic of China.
Wang Z; Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing, 100081, People's Republic of China.
Wang X; Team of Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, People's Republic of China.
Wang J; Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing, 100081, People's Republic of China.

Appl Microbiol Biotechnol ; 103(13): 5193-5213, 2019 Jul.

Article em En | MEDLINE | ID: mdl-31025073

Assuntos

Antibacterianos/farmacologia; Biofilmes/efeitos dos fármacos; Defensinas/farmacologia; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Animais; Quimiocina CCL2/genética; Quimiocina CCL2/imunologia; Defensinas/genética; Descoberta de Drogas; Farmacorresistência Bacteriana Múltipla; Feminino; Interleucina-10/genética; Interleucina-10/imunologia; Camundongos; Testes de Sensibilidade Microbiana; Peritonite/tratamento farmacológico; Peritonite/microbiologia; Pichia/genética; Células RAW 264.7; Infecções Estafilocócicas; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/imunologia; Vancomicina/farmacologia

Palavras-chave

Anti-biofilm ability; Defensin-like peptides; Intracellular activity; Mechanism of action; Recombinant; S. aureus

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biofilmes / Defensinas / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Appl Microbiol Biotechnol Ano de publicação: 2019 Tipo de documento: Article

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