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In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.
Lin, Brian Leei; Matera, Damian; Doerner, Julia F; Zheng, Nan; Del Camino, Donato; Mishra, Sumita; Bian, Hong; Zeveleva, Svetlana; Zhen, Xiaoguang; Blair, Nathaniel T; Chong, Jayhong A; Hessler, David P; Bedja, Djahida; Zhu, Guangshuo; Muller, Grace K; Ranek, Mark J; Pantages, Lynn; McFarland, Mary; Netherton, Matthew R; Berry, Angela; Wong, Diane; Rast, Georg; Qian, Hu Sheng; Weldon, Steven M; Kuo, Jay J; Sauer, Achim; Sarko, Chris; Moran, Magdalene M; Kass, David A; Pullen, Steven S.
Afiliação
  • Lin BL; Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
  • Matera D; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Doerner JF; Hydra Biosciences, Cambridge, MA 02138.
  • Zheng N; Hydra Biosciences, Cambridge, MA 02138.
  • Del Camino D; Hydra Biosciences, Cambridge, MA 02138.
  • Mishra S; Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
  • Bian H; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Zeveleva S; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Zhen X; Hydra Biosciences, Cambridge, MA 02138.
  • Blair NT; Hydra Biosciences, Cambridge, MA 02138.
  • Chong JA; Hydra Biosciences, Cambridge, MA 02138.
  • Hessler DP; Hydra Biosciences, Cambridge, MA 02138.
  • Bedja D; Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
  • Zhu G; Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
  • Muller GK; Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
  • Ranek MJ; Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
  • Pantages L; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • McFarland M; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Netherton MR; Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Berry A; Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Wong D; Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Rast G; Drug Discovery Sciences, Boehringer Ingelheim GmbH & Co. KG, 88397 Biberach an der Riss, Germany.
  • Qian HS; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Weldon SM; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Kuo JJ; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Sauer A; Drug Discovery Sciences, Boehringer Ingelheim GmbH & Co. KG, 88397 Biberach an der Riss, Germany.
  • Sarko C; Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
  • Moran MM; Hydra Biosciences, Cambridge, MA 02138.
  • Kass DA; Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205; dkass@jhmi.edu steven.pullen@boehringer-ingelheim.com.
  • Pullen SS; Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877; dkass@jhmi.edu steven.pullen@boehringer-ingelheim.com.
Proc Natl Acad Sci U S A ; 116(20): 10156-10161, 2019 05 14.
Article em En | MEDLINE | ID: mdl-31028142
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomegalia / Canal de Cátion TRPC6 / Nefroesclerose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomegalia / Canal de Cátion TRPC6 / Nefroesclerose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article