Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
J Periodontal Res
; 54(5): 546-554, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31032950
ABSTRACT
BACKGROUND AND OBJECTIVE:
CYP1A1 rs1048943 polymorphism was reported to be correlated with periodontitis; however, its association with aggressive periodontitis (AgP) has not yet been investigated. The aim of the study was to investigate the association between the CYP1A1 gene rs1048943 variant with generalized aggressive periodontitis (GAgP) and platelet activation and analyse whether its interaction with hyperlipidemia affects periodontal status in a Chinese population.METHODS:
A case-control study of 224 GAgP patients and 139 healthy controls was conducted. The clinical parameters of probing depth (PD), attachment loss (AL) and bleeding index (BI) were recorded. Platelet count (PLT), platelet distribution width (PDW), platelet large cell ratio (PLCR), mean platelet volume (MPV), serum total cholesterol (TC), triacylglycerol (TG), high and low-density lipoprotein (HDL and LDL) were also measured. The CYP1A1 rs1048943 SNP was genotyped by time-of-flight mass spectrometry. Logistic and linear regression models were used to measure correlation.RESULTS:
The CYP1A1 rs1048943 AG/GG genotype was associated with GAgP (OR = 1.56, 95%CI 1.01, 2.42), PD, AL and decreased PDW, PLCR and MPV after adjustment for covariates. Gene-lipid interactions were found between CYP1A1 rs1048943 and HDL for PD (Pinteraction = 0.0033), BI (Pinteraction = 0.0311) and AL (Pinteraction = 0.0141) and between CYP1A1 rs1048943 and LDL for PD (Pinteraction = 0.013) among patients with GAgP.CONCLUSION:
The G allele of the CYP1A1 rs1048943 gene was associated with GAgP, periodontal status and platelet-related inflammation status in a Chinese population. Hyperlipidemia could modulate the effect of CYP1A1 rs1048943 on the periodontal status of GAgP.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Periodontite Agressiva
/
Citocromo P-450 CYP1A1
/
Hiperlipidemias
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Periodontal Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China