LncRNA-SULT1C2A regulates Foxo4 in congenital scoliosis by targeting rno-miR-466c-5p through PI3K-ATK signalling.

Chen, Chong; Tan, Haining; Bi, Jiaqi; Li, Lin; Rong, Tianhua; Lin, Youxi; Sun, Peiyu; Liang, Jinqian; Jiao, Yang; Li, Zheng; Sun, Liang; Shen, Jianxiong

Chen, Chong; Tan, Haining; Bi, Jiaqi; Li, Lin; Rong, Tianhua; Lin, Youxi; Sun, Peiyu; Liang, Jinqian; Jiao, Yang; Li, Zheng; Sun, Liang; Shen, Jianxiong.

Afiliação

Chen C; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Tan H; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Bi J; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Li L; Beijing Zhongke Jingyun Technology Company Ltd., Beijing, China.
Rong T; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Lin Y; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Sun P; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Liang J; Department of Orthopedics Surgery, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Jiao Y; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Li Z; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Sun L; Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Shen J; Beijing Zhongke Jingyun Technology Company Ltd., Beijing, China.

J Cell Mol Med ; 23(7): 4582-4591, 2019 07.

Article em En | MEDLINE | ID: mdl-31044535

Assuntos

Fatores de Transcrição Forkhead/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; RNA Longo não Codificante/metabolismo; Escoliose/congênito; Escoliose/genética; Transdução de Sinais; Regiões 3' não Traduzidas/genética; Animais; Sequência de Bases; Regulação para Baixo/genética; Embrião de Mamíferos/metabolismo; Fatores de Transcrição Forkhead/genética; Regulação da Expressão Gênica no Desenvolvimento; Genes Reporter; Células HEK293; Humanos; Luciferases/metabolismo; MicroRNAs; Modelos Biológicos; Organogênese/genética; RNA Longo não Codificante/genética; Ratos Sprague-Dawley; Somitos/embriologia; Deficiência de Vitamina A/embriologia; Deficiência de Vitamina A/genética

Palavras-chave

Foxo4; PI3K-AKT; SULT1C2A; congenital scoliosis (CS); rno-miR-466c-5p; somitogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Escoliose / Transdução de Sinais / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Fatores de Transcrição Forkhead / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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