Copper-Catalyzed Alkylarylation of Unactivated Alkenes: Synthesis of 3-Alkyl Indolines from N-Allyl Anilines and Alkanes.
Chem Asian J
; 14(11): 1932-1936, 2019 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-31046195
ABSTRACT
A rare example of C(sp3 )-H functionalization of simple alkanes with unactivated alkenes is presented. In the presence of a copper salt and di-tert-butyl peroxide (DTBP), N-allyl anilines underwent exo-selective alkylation/cyclization cascade with unactivated alkenic bonds as radical acceptors and simple alkanes as radical precursors, providing a direct access to 3-alkyl indolines. The present protocol features simple operation, broad substrate scope and great exo selectivity.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Asian J
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China