The role of small intestinal bacterial overgrowth in the pathogenesis of hyperlipidemia.
Wiad Lek
; 72(4): 645-649, 2019.
Article
em En
| MEDLINE
| ID: mdl-31055549
ABSTRACT
OBJECTIVE:
Introduction:
Small intestinal bacterial overgrowth may cause the hyperlipidemia appearance by enterohepatic circulation disturbance which evolves on the background of the early bile acids deconjugation with further endotoxin production and oxidative stress in the liver with hyperproduction of cholesterol and atherogenic lipoproteins. Theaim:
the determination of prevalence and features of SIBO in a series of patients with hyperlipidemia and in control subjects. PATIENTS ANDMETHODS:
Materials andmethods:
Nineteen patients with hyperlipidemia and ten control subjects were studied. Small intestinal bacterial overgrowth was assessed by a lactulose breath test. Such biochemical markers as CRP, ALT, AST, GGTP, apolipoprotein B, bilirubin, cholesterol and lipid profile were determined. Except the routine interpretation of lactulose breath test, which contains the SIBO detection, small intestinal transit time and hydrogen level evaluation with next comparison between groups of patients was realized.RESULTS:
Results:
Small intestinal bacterial overgrowth was present in 78.9% of patients with hyperlipidemia and 40% in control subjects. The maximal dose of H2 was particularly higher in patients with hyperlipidemia in comparison with control group (94,7±13,69 vs. 36,13±5,4). There was a strong correlation between AST level and SIBO existence in both groups (r=1). Positive connection between LDL, TG, VLDL and the dose of exhaled hydrogen on 120 minute (r=0.6, r= 0.62, r=0.7 respectively) and strong negative correlation between HDL and 120 minute dose (r=-0.74) in main group was marked.CONCLUSION:
Conclusions:
Patients with hyperlipidemia have a higher prevalence of small intestinal bacterial overgrowth and there is a relationship between H2 rate and LDL, TG, VLDL.Palavras-chave
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Disbiose
/
Hiperlipidemias
/
Intestino Delgado
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Wiad Lek
Assunto da revista:
MEDICINA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Ucrânia