Outbreak of aseptic meningitis caused by echovirus 30 in Kushiro, Japan in 2017.
J Clin Virol
; 116: 34-38, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31082730
ABSTRACT
BACKGROUND:
Echovirus 30 (E30) is one of the most common causative agents for aseptic meningitis.OBJECTIVES:
In the autumn of 2017, there was an outbreak caused by E30 in Kushiro, Hokkaido, Japan. The aim of this study was to characterize this outbreak. STUDYDESIGN:
Fifty-nine patients were admitted to the Department of Pediatrics, Kushiro Red Cross Hospital (KRCH) with clinical diagnosis of aseptic meningitis. Among those, 36 patients were finally diagnosed as E30-associated aseptic meningitis by the detection of viral RNA using reverse transcription-polymerase chain reaction (RT-PCR) and/or the evidence of more than four-fold rise in neutralizing antibody (NA) titers in the convalescent phase relative to those in the acute phase. We investigated these 36 confirmed cases.RESULTS:
The median age was 6 years (range 6 months-14 years). The positive signs and symptoms were as follows fever (100%), headache (94%), vomiting (92%), jolt accentuation (77%), neck stiffness (74%), Kernig sign (29%), and abdominal pain (28%). The median cerebrospinal fluid (CSF) white cell count, neutrophil count, and lymphocyte count were 222/µL (range 3-1434/µL), 144/µL (range 1-1269/µL), and 85/µL (range 2-354/µL), respectively. Although the detected viral genes demonstrated same cluster, they were different from E30 strains observed in Japan between 2010 and 2014.CONCLUSION:
We mainly showed clinical and virological features of the E30-associated aseptic meningitis outbreak that occurred in Kushiro. To prevent further spread of E30 infection, continuous surveillance of enterovirus (EV) circulation and standard precautions are considered essential.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
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Enterovirus Humano B
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Infecções por Echovirus
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Meningite Asséptica
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Clin Virol
Assunto da revista:
VIROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article