Longitudinal atopic dermatitis control and persistence vary with timing of disease onset in children: A cohort study.
J Am Acad Dermatol
; 81(6): 1292-1299, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-31085263
ABSTRACT
BACKGROUND:
Wide variation exists in the timing of atopic dermatitis (AD) disease onset among children. Distinct trajectories of early-onset, mid-onset, and late-onset AD have been previously described.OBJECTIVE:
To evaluate longitudinal disease control and persistence with respect to age at onset of AD.METHODS:
A cohort study was performed using the Pediatric Eczema Elective Registry, a prospective observational cohort of subjects with childhood-onset AD. AD control and persistence were assessed biannually for up to 10 years.RESULTS:
A total of 8015 subjects with 41,934 person-years of follow-up were included. In longitudinal analyses using generalized linear latent and mixed modeling, older age at onset of AD was associated with better disease control and less-persistent AD. For each additional year of age at onset of AD, the adjusted odds ratios for poorer AD control and for persistent AD were 0.93 (95% confidence interval, 0.91-0.94) and 0.84 (95% confidence interval, 0.80-0.88), respectively. Differences in AD control and persistence among subjects with early-, mid-, and late-onset AD were most pronounced from early adolescence onward.LIMITATIONS:
Misclassification bias may arise from using self-reported data on age at onset. Attrition and missing data in longitudinal studies may introduce bias.CONCLUSION:
Early-, mid-, and late-onset pediatric AD appear to be clinically distinct subtypes of the disease.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema de Registros
/
Gerenciamento Clínico
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Dermatite Atópica
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2019
Tipo de documento:
Article