Infection of human pegivirus 2 (HPgV-2) is associated with hepatitis C virus but not hepatitis B virus infection in people who inject drugs.
J Gen Virol
; 100(6): 968-974, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-31090532
ABSTRACT
We evaluated the association between human pegivirus-2 (HPgV-2) infection and hepatitis C virus (HCV)/hepatitis B virus (HBV) co-infection in 745 plasma samples collected from HCV-positive but human immunodeficiency virus type one (HIV-1)-negative people who inject drugs in Hunan, China. The prevalence of anti-HPgV-2 was 4.43 â% (33/745) and, within this, the HCV 6a genotype showed significantly higher prevalence as compared with the HCV non-6a genotypes, 6.29 â% (18/286) vs. 1.69â % (4/236), respectively (P=0.009). HPgV-2 RNA was detected in 2.15 â% (16/745), and was not significantly different between the HCV 6a and non-6a genotypes, 2.45 â% (7/286) vs. 2.54â % (6/236), respectively (P =0.945). HBV single infection did not increase the risk of HPgV-2 infection. Compared with HCV single infection, HCV/HBV co-infection increased the risk of HPgV-2 infection by about three-fold odds ratio (OR)=3.24 [95â % confidence interval (CI) 1.34-7.82, P=0.014] according to anti-HPgV-2 positivity or OR=3.51 (95 â% CI 1.15-10.74, P=0.051) according to HPgV-2 viraemia. HPgV-2 infection did not increase the levels of liver-specific enzymes. Our study provides new findings regarding the association between HPgV-2 and HCV genotypes as well as HCV/HBV co-infection.
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Base de dados:
MEDLINE
Assunto principal:
Hepatite C
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Infecções por Flaviviridae
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Coinfecção
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Hepatite B
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Injeções
Tipo de estudo:
Etiology_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Gen Virol
Ano de publicação:
2019
Tipo de documento:
Article