Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells.

Chen, Bi; Sun, Yongjin; Zhang, Juntao; Zhu, Qingwei; Yang, Yunlong; Niu, Xin; Deng, Zhifeng; Li, Qing; Wang, Yang

Chen, Bi; Sun, Yongjin; Zhang, Juntao; Zhu, Qingwei; Yang, Yunlong; Niu, Xin; Deng, Zhifeng; Li, Qing; Wang, Yang.

Afiliação

Chen B; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Sun Y; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Zhang J; Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Zhu Q; Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Yang Y; Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Niu X; Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Deng Z; Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Li Q; Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. liqing_236@aliyun.com.
Wang Y; Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. wangy63cn@126.com.

Stem Cell Res Ther ; 10(1): 142, 2019 05 21.

Article em En | MEDLINE | ID: mdl-31113469

Assuntos

Exossomos/transplante; Proteína 1 Associada a ECH Semelhante a Kelch/genética; MicroRNAs/genética; Fator 2 Relacionado a NF-E2/genética; Úlcera por Pressão/terapia; Animais; Senescência Celular/genética; Células Endoteliais/transplante; Exossomos/genética; Regulação da Expressão Gênica no Desenvolvimento; Células-Tronco Embrionárias Humanas/transplante; Células Endoteliais da Veia Umbilical Humana; Humanos; Camundongos; Neovascularização Fisiológica/genética; Úlcera por Pressão/genética; Úlcera por Pressão/patologia; Regeneração/genética; Cicatrização/genética

Palavras-chave

Angiogenesis; Embryonic stem cells; Exosomes; Nrf2; Senescence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Úlcera por Pressão / MicroRNAs / Fator 2 Relacionado a NF-E2 / Exossomos / Proteína 1 Associada a ECH Semelhante a Kelch Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Stem Cell Res Ther Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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