Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.

Pearson, Stephanie; Loft, Anne; Rajbhandari, Prashant; Simcox, Judith; Lee, Sanghoon; Tontonoz, Peter; Mandrup, Susanne; Villanueva, Claudio J

Pearson, Stephanie; Loft, Anne; Rajbhandari, Prashant; Simcox, Judith; Lee, Sanghoon; Tontonoz, Peter; Mandrup, Susanne; Villanueva, Claudio J.

Afiliação

Pearson S; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Loft A; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Rajbhandari P; Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA.
Simcox J; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Lee S; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Tontonoz P; Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA.
Mandrup S; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Villanueva CJ; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.

Genes Dev ; 33(13-14): 747-762, 2019 07 01.

Article em En | MEDLINE | ID: mdl-31123067

Assuntos

Adipócitos Bege/metabolismo; Proteínas Correpressoras/genética; Proteínas Correpressoras/metabolismo; Glucose/metabolismo; Animais; Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Células Cultivadas; Dieta Hiperlipídica; Metabolismo Energético/genética; Deleção de Genes; Regulação da Expressão Gênica/genética; Estudo de Associação Genômica Ampla; Resistência à Insulina/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Mitocôndrias/genética; Mitocôndrias/metabolismo; Termogênese/genética

Palavras-chave

TLE3; adipocytes; beige adipocytes; development; diabetes; metabolism; thermogenesis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Correpressoras / Adipócitos Bege / Glucose Limite: Animals Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google