AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats.

Qin, Chunhua; Aslamkhan, Amy G; Pearson, Kara; Tanis, Keith Q; Podtelezhnikov, Alexei; Frank, Erika; Pacchione, Stephen; Pippert, Todd; Glaab, Warren E; Sistare, Frank D

Qin, Chunhua; Aslamkhan, Amy G; Pearson, Kara; Tanis, Keith Q; Podtelezhnikov, Alexei; Frank, Erika; Pacchione, Stephen; Pippert, Todd; Glaab, Warren E; Sistare, Frank D.

Afiliação

Qin C; Department of Safety Assessment and Laboratory Animal Resources.
Aslamkhan AG; Department of Safety Assessment and Laboratory Animal Resources.
Pearson K; Department of Safety Assessment and Laboratory Animal Resources.
Tanis KQ; Department of Human Genetics and Pharmacogenomics, Merck & Co., Inc., West Point, Pennsylvania 19486.
Podtelezhnikov A; Department of Human Genetics and Pharmacogenomics, Merck & Co., Inc., West Point, Pennsylvania 19486.
Frank E; Department of Safety Assessment and Laboratory Animal Resources.
Pacchione S; Department of Safety Assessment and Laboratory Animal Resources.
Pippert T; Department of Safety Assessment and Laboratory Animal Resources.
Glaab WE; Department of Safety Assessment and Laboratory Animal Resources.
Sistare FD; Department of Safety Assessment and Laboratory Animal Resources.

Toxicol Sci ; 171(1): 46-55, 2019 Sep 01.

Article em En | MEDLINE | ID: mdl-31127949

Palavras-chave

Cyp1a; aryl hydrocarbon receptor; biomarker; carcinogenicity; threshold

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies Idioma: En Revista: Toxicol Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google