Depopulation of dense &#945;-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.

Wegrzynowicz, Michal; Bar-On, Dana; Calo', Laura; Anichtchik, Oleg; Iovino, Mariangela; Xia, Jing; Ryazanov, Sergey; Leonov, Andrei; Giese, Armin; Dalley, Jeffrey W; Griesinger, Christian; Ashery, Uri; Spillantini, Maria Grazia

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.

Wegrzynowicz, Michal; Bar-On, Dana; Calo', Laura; Anichtchik, Oleg; Iovino, Mariangela; Xia, Jing; Ryazanov, Sergey; Leonov, Andrei; Giese, Armin; Dalley, Jeffrey W; Griesinger, Christian; Ashery, Uri; Spillantini, Maria Grazia.

Afiliação

Wegrzynowicz M; Department of Clinical Neurosciences, University of Cambridge, The Clifford Allbutt Building, Cambridge, CB2 0AH, UK.
Bar-On D; School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv, Israel.
Calo' L; Sagol School of Neuroscience, Tel Aviv University, 69978, Tel Aviv, Israel.
Anichtchik O; Department of Clinical Neurosciences, University of Cambridge, The Clifford Allbutt Building, Cambridge, CB2 0AH, UK.
Iovino M; Department of Clinical Neurosciences, University of Cambridge, The Clifford Allbutt Building, Cambridge, CB2 0AH, UK.
Xia J; Department of Clinical Neurosciences, University of Cambridge, The Clifford Allbutt Building, Cambridge, CB2 0AH, UK.
Ryazanov S; Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
Leonov A; Max Planck Institute for Biophysical Chemistry, 37077, Göttingen, Germany.
Giese A; DFG Research Centre Nanoscale Microscopy and Molecular Physiology of the Brain, 37070, Göttingen, Germany.
Dalley JW; Max Planck Institute for Biophysical Chemistry, 37077, Göttingen, Germany.
Griesinger C; DFG Research Centre Nanoscale Microscopy and Molecular Physiology of the Brain, 37070, Göttingen, Germany.
Ashery U; Center for Neuropathology and Prion Research, Ludwig Maximilians University Munich, 81377, Munich, Germany.
Spillantini MG; Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.

Acta Neuropathol ; 138(4): 575-595, 2019 10.

Article em En | MEDLINE | ID: mdl-31165254

Assuntos

Morte Celular/fisiologia; Neurônios Dopaminérgicos/patologia; Doença de Parkinson/patologia; Agregação Patológica de Proteínas/patologia; Substância Negra/patologia; alfa-Sinucleína/metabolismo; Animais; Modelos Animais de Doenças; Marcha/genética; Camundongos; Camundongos Transgênicos; Atividade Motora/genética; Doença de Parkinson/genética; Doença de Parkinson/metabolismo; Agregação Patológica de Proteínas/metabolismo; Substância Negra/metabolismo; Tirosina 3-Mono-Oxigenase/metabolismo; alfa-Sinucleína/genética

Palavras-chave

Alpha-synuclein; Anle138b; Mouse model; Parkinson's disease; Striatum; Substantia nigra; dSTORM

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Substância Negra / Morte Celular / Alfa-Sinucleína / Neurônios Dopaminérgicos / Agregação Patológica de Proteínas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Acta Neuropathol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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