Asymmetric Total Synthesis of (+)-Neooxazolomycin Using a Chirality-Transfer Strategy.
Angew Chem Int Ed Engl
; 58(32): 11018-11022, 2019 08 05.
Article
em En
| MEDLINE
| ID: mdl-31168911
ABSTRACT
The total synthesis of (+)-neooxazolomycin was achieved from the amino-acid d-serine. The efficiency of this approach is derived from the use of principles of memory of chirality and dynamic kinetic resolution in the intramolecular aldol reaction of a serine derivative to build the densely functionalized lactam framework and to install three contiguous stereocenters. The key intermediate was readily elaborated to the target natural product.
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MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2019
Tipo de documento:
Article