An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion.

Thornton, L Brock; Teehan, Paige; Floyd, Katherine; Cochrane, Christian; Bergmann, Amy; Riegel, Bryce; Stasic, Andrew J; Di Cristina, Manlio; Moreno, Silvia N J; Roepe, Paul D; Dou, Zhicheng

Thornton, L Brock; Teehan, Paige; Floyd, Katherine; Cochrane, Christian; Bergmann, Amy; Riegel, Bryce; Stasic, Andrew J; Di Cristina, Manlio; Moreno, Silvia N J; Roepe, Paul D; Dou, Zhicheng.

Afiliação

Thornton LB; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Teehan P; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Floyd K; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Cochrane C; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Bergmann A; Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Riegel B; Department of Chemistry, Georgetown University, NW, Washington DC, United States of America.
Stasic AJ; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, NW, Washington DC, United States of America.
Di Cristina M; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.
Moreno SNJ; Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America.
Roepe PD; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Dou Z; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.

PLoS Pathog ; 15(6): e1007775, 2019 06.

Article em En | MEDLINE | ID: mdl-31170269

Assuntos

Cloroquina/farmacologia; Endossomos; Lisossomos; Proteínas de Membrana Transportadoras; Plasmodium falciparum; Proteínas de Protozoários; Toxoplasma; Toxoplasmose; Linhagem Celular; Endossomos/metabolismo; Endossomos/parasitologia; Humanos; Lisossomos/metabolismo; Lisossomos/parasitologia; Proteínas de Membrana Transportadoras/genética; Proteínas de Membrana Transportadoras/metabolismo; Plasmodium falciparum/genética; Plasmodium falciparum/metabolismo; Plasmodium falciparum/patogenicidade; Proteínas de Protozoários/genética; Proteínas de Protozoários/metabolismo; Toxoplasma/genética; Toxoplasma/metabolismo; Toxoplasma/patogenicidade; Toxoplasmose/genética; Toxoplasmose/metabolismo; Toxoplasmose/patologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Plasmodium falciparum / Endossomos / Toxoplasma / Proteínas de Protozoários / Toxoplasmose / Cloroquina / Lisossomos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: PLoS Pathog Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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