Biochemical comparative studies between eye- and brain-derived growth factors.
Biochimie
; 69(5): 511-6, 1987 May.
Article
em En
| MEDLINE
| ID: mdl-3118966
ABSTRACT
Two bovine brain-derived growth factors, BDGF I and BDGF II, were isolated using the same extraction procedure as previously described for eye-derived growth factors (EDGF). The hypothesis that these growth factors were identical to EDGF I and EDGF II, respectively, was supported by their similar molecular weights (16,000 and 15,000, respectively) and isoelectric points (9.0 and 5.0, respectively), their identical retention behavior on reverse-phase chromatography and their similar amino acid compositions. From studies on their binding properties to cell surfaces, competition between EDGF I and BDGF I as well as competition between EDGF II and BDGF II to the same receptor was observed. The amino terminal sequence of EDGF II (1-16) was shown to be identical to the amino acid residues (7-22) of the acidic FGF, strongly confirming our observations on the identity of the factors isolated from bovine brain and retina.
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Química Encefálica
/
Substâncias de Crescimento
Limite:
Animals
Idioma:
En
Revista:
Biochimie
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
França