Synthesis of glycopolymers with specificity for bacterial strains via bacteria-guided polymerization.
Chem Sci
; 10(20): 5251-5257, 2019 May 28.
Article
em En
| MEDLINE
| ID: mdl-31191880
ABSTRACT
Identifying probiotics and pathogens is of great interest to the health of the human body. It is critical to develop microbiota-targeted therapies to have high specificity including strain specificity. In this study, we have utilized E. coli MG1655 bacteria as living templates to synthesize glycopolymers in situ with high selectivity. By this bacteria-sugar monomer-aptation-polymerization (BS-MAP) method, we have obtained glycopolymers from the surface of bacteria which can recognize template bacteria from two strains of E. coli and the specific bacteria-binding ability of glycopolymers was confirmed by both bacterial aggregation experiment and QCM-D measurements. Furthermore, the synthesized glycopolymers have shown a powerful inhibitory ability which can prevent bacteria from harming cells in both anti-infection and co-culture tests.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Sci
Ano de publicação:
2019
Tipo de documento:
Article