Liver disease-associated keratin 8 and 18 mutations modulate keratin acetylation and methylation.

Jang, Kwi-Hoon; Yoon, Han-Na; Lee, Jongeun; Yi, Hayan; Park, Sang-Yoon; Lee, So-Young; Lim, Younglan; Lee, Hyoung-Joo; Cho, Jin-Won; Paik, Young-Ki; Hancock, Williams S; Ku, Nam-On

Jang, Kwi-Hoon; Yoon, Han-Na; Lee, Jongeun; Yi, Hayan; Park, Sang-Yoon; Lee, So-Young; Lim, Younglan; Lee, Hyoung-Joo; Cho, Jin-Won; Paik, Young-Ki; Hancock, Williams S; Ku, Nam-On.

Afiliação

Jang KH; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Yoon HN; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Lee J; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Yi H; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Park SY; Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Lee SY; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Lim Y; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Lee HJ; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Cho JW; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Paik YK; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.
Hancock WS; Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
Ku NO; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, Korea.

FASEB J ; 33(8): 9030-9043, 2019 08.

Article em En | MEDLINE | ID: mdl-31199680

Assuntos

Queratina-18/genética; Queratina-18/metabolismo; Queratina-8/genética; Queratina-8/metabolismo; Hepatopatias/genética; Hepatopatias/metabolismo; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Acetilação; Sequência de Aminoácidos; Substituição de Aminoácidos; Animais; Sítios de Ligação/genética; Linhagem Celular; Cricetinae; Células HT29; Humanos; Queratina-18/química; Queratina-8/química; Corpos de Mallory/metabolismo; Metilação; Proteínas Mutantes/química; Mutação de Sentido Incorreto; Processamento de Proteína Pós-Traducional; Estabilidade Proteica; Espectrometria de Massas em Tandem

Palavras-chave

MDB; intermediate filament; post-translational modification; protein stability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Mutantes / Queratina-18 / Queratina-8 / Hepatopatias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article

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