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Fc Glycan-Mediated Regulation of Placental Antibody Transfer.
Jennewein, Madeleine F; Goldfarb, Ilona; Dolatshahi, Sepideh; Cosgrove, Cormac; Noelette, Francesca J; Krykbaeva, Marina; Das, Jishnu; Sarkar, Aniruddh; Gorman, Matthew J; Fischinger, Stephanie; Boudreau, Carolyn M; Brown, Joelle; Cooperrider, Jennifer H; Aneja, Jasneet; Suscovich, Todd J; Graham, Barney S; Lauer, Georg M; Goetghebuer, Tessa; Marchant, Arnaud; Lauffenburger, Douglas; Kim, Arthur Y; Riley, Laura E; Alter, Galit.
Afiliação
  • Jennewein MF; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Goldfarb I; Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Dolatshahi S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Cosgrove C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Noelette FJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Krykbaeva M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Das J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Sarkar A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Gorman MJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Fischinger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Boudreau CM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Brown J; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Cooperrider JH; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Aneja J; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Suscovich TJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA.
  • Lauer GM; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Goetghebuer T; Department of Pediatrics, Hôpital Saint-Pierre, Brussels 1000, Belgium.
  • Marchant A; Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi 6041, Belgium.
  • Lauffenburger D; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Gynepathology Research, Cambridge, MA 02139, USA.
  • Kim AY; Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Riley LE; Department of Obstetrics and Gynecology, New York Presbyterian/Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address: lar9110@med.cornell.edu.
  • Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@mgh.harvard.edu.
Cell ; 178(1): 202-215.e14, 2019 06 27.
Article em En | MEDLINE | ID: mdl-31204102
ABSTRACT
Despite the worldwide success of vaccination, newborns remain vulnerable to infections. While neonatal vaccination has been hampered by maternal antibody-mediated dampening of immune responses, enhanced regulatory and tolerogenic mechanisms, and immune system immaturity, maternal pre-natal immunization aims to boost neonatal immunity via antibody transfer to the fetus. However, emerging data suggest that antibodies are not transferred equally across the placenta. To understand this, we used systems serology to define Fc features associated with antibody transfer. The Fc-profile of neonatal and maternal antibodies differed, skewed toward natural killer (NK) cell-activating antibodies. This selective transfer was linked to digalactosylated Fc-glycans that selectively bind FcRn and FCGR3A, resulting in transfer of antibodies able to efficiently leverage innate immune cells present at birth. Given emerging data that vaccination may direct antibody glycosylation, our study provides insights for the development of next-generation maternal vaccines designed to elicit antibodies that will most effectively aid neonates.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Polissacarídeos / Imunoglobulina G / Receptores Fc / Antígenos de Histocompatibilidade Classe I Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Newborn / Pregnancy País/Região como assunto: America do norte / Europa Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Polissacarídeos / Imunoglobulina G / Receptores Fc / Antígenos de Histocompatibilidade Classe I Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Newborn / Pregnancy País/Região como assunto: America do norte / Europa Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos