Germ granules in Drosophila.
Traffic
; 20(9): 650-660, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31218815
ABSTRACT
Germ granules are hallmarks of all germ cells. Early ultrastructural studies in Drosophila first described these membraneless granules in the oocyte and early embryo as filled with amorphous to fibrillar material mixed with RNA. Genetic studies identified key protein components and specific mRNAs that regulate germ cell-specific functions. More recently these ultrastructural studies have been complemented by biophysical analysis describing germ granules as phase-transitioned condensates. In this review, we provide an overview that connects the composition of germ granules with their function in controlling germ cell specification, formation and migration, and illuminate these mysterious condensates as the gatekeepers of the next generation.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Grânulos Citoplasmáticos
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Drosophila melanogaster
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Células Germinativas
Limite:
Animals
Idioma:
En
Revista:
Traffic
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article