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Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors.
Liao, Mingxiang; Watkins, Simon; Nash, Eileen; Isaacson, Jeff; Etter, Jeff; Beltman, Jeri; Fan, Rong; Shen, Li; Mutlib, Abdul; Kemeny, Vendel; Pápai, Zsuzsanna; van Tilburg, Pascal; Xiao, Jim J.
Afiliação
  • Liao M; Clovis Oncology, Inc., 500 Flatiron Pkwy, Suite 100, Boulder, CO, 80301, USA.
  • Watkins S; Clovis Oncology, Inc., 500 Flatiron Pkwy, Suite 100, Boulder, CO, 80301, USA.
  • Nash E; Clovis Oncology, Inc., 500 Flatiron Pkwy, Suite 100, Boulder, CO, 80301, USA.
  • Isaacson J; Clovis Oncology, Inc., 500 Flatiron Pkwy, Suite 100, Boulder, CO, 80301, USA.
  • Etter J; Clovis Oncology, Inc., 500 Flatiron Pkwy, Suite 100, Boulder, CO, 80301, USA.
  • Beltman J; Clovis Oncology, Inc., 500 Flatiron Pkwy, Suite 100, Boulder, CO, 80301, USA.
  • Fan R; Frontage Laboratories, Inc., 700 Pennsylvania Dr, Exton, PA, 19341, USA.
  • Shen L; Frontage Laboratories, Inc., 700 Pennsylvania Dr, Exton, PA, 19341, USA.
  • Mutlib A; Frontage Laboratories, Inc., 700 Pennsylvania Dr, Exton, PA, 19341, USA.
  • Kemeny V; PRA Health Sciences, Rottenbiller utca 13, Budapest, H-1077, Hungary.
  • Pápai Z; State Health Center, Róbert Károly krt. 44, Budapest, 1134, Hungary.
  • van Tilburg P; PRA Health Sciences, Bioanalytical Laboratory NL, Amerikaweg 18, 9407, TK, Assen, The Netherlands.
  • Xiao JJ; Clovis Oncology, Inc., 500 Flatiron Pkwy, Suite 100, Boulder, CO, 80301, USA. jxiao@clovisoncology.com.
Invest New Drugs ; 38(3): 765-775, 2020 06.
Article em En | MEDLINE | ID: mdl-31250355
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radioisótopos de Carbono / Inibidores de Poli(ADP-Ribose) Polimerases / Indóis / Neoplasias / Antineoplásicos Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radioisótopos de Carbono / Inibidores de Poli(ADP-Ribose) Polimerases / Indóis / Neoplasias / Antineoplásicos Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos